Yes. Pyrithione Zinc (PZ) is insoluble in water and not easily absorbed through skin when topically applied or easily absorbed through mucous membranes if swallowed.

Data from evaluated studies by the Federal Drug Administration (FDA) showed that topically applied PZ has a high safety margin.

With PZ there is no contact sensitization or photosensitization.

Federal Register of FDA (1982) “Proposed Rules” for “OTC Drug Products for the Control of Dandruff, Seborrheic Dermatitis and Psoriasis; Establishment of a monograph” p.54664-54666.